Jesus has gone back “home” to Capernaum after being on the mountain with His disciples and appointing the twelve to be apostles.
In the city, He is immediately surrounded by great crowds of people wanting healing, deliverance, and to hear his teaching.
His family (mom and siblings) come to rescue Him, saying “He’s out of His mind.” They couldn’t understand Jesus’ total willingness to be accessible to the crowds; to have them impose on Him constantly.
(Who of us would be wiling for this?)
Officials from Jerusalem also batter Him with accusations (they will later batter him with slaps and fists and spitting before sending Him to Pilate to be tortured and killed), saying “He has an ‘unclean’ spirit! He does these miracles by the power of Satan!”
Jesus rebukes them with severe judgement. Blasphemy against anyone – even Himself – can be forgiven, but NOT blasphemy against the Spirit of God. Jesus was indwelt by the HOLY spirit, and to call Him “a unclean spirit” (a demon) is truly unforgivable…for eternity. They knew what Jesus was claiming about Himself – to be their Messiah, the Son of God – and they rejected Him, saying He was empowered by Satan.
(It freaks me out to just type that!)
Again Jesus’ family calls to Him from the periphery of the crowd, concerned that He needs food and rest (a typical Jewish mother).
Jesus gently rebukes his natural family, knowing their hearts were unbelieving at this point, but not vicious against him like the Jewish officials. He reminds them (again) that He has to be about His (heavenly) Father’s business, and that those who are sitting around him, eagerly hearing His words and believing in Him (which is the will of God – see John 6:40) are his SPIRITUAL brothers, sisters and mother.
(PS: We know that later His mother, Mary, and His brothers James and Jude believe in Jesus, and maybe other siblings too.)